Cautions and limits
The label’s own caution first, then the federal limits on the four vitamin rows, then the questions about this combination that nobody has answered.
Quick answer
No side effect is published for this formula and no safety study of the combination exists in the supplied material, which is an absence rather than a record. ODS says taking high amounts of vitamin B6 for a year or longer can cause severe nerve damage, with a 100 mg federal limit and a 12 mg EFSA figure; this label prints 1.7 mg, and that restraint deserves credit. Folate is printed at 383 mcg DFE against an upper limit of 1,000 mcg, so it sits at well under half of it — which has to be said first, because ODS also warns that large folate doses “might hide” a vitamin B12 deficiency. Alpha lipoic acid at 400 mg and benfotiamine at 150 mg are not trivial amounts.
4 groups the caution names
Printed exactly as the bottle prints it, before anything this desk has to add.
Start with the safety text the manufacturer actually wrote, exactly as the bottle prints it. It is short, it is unhedged, and it is the only caution on this product that came from whoever made it.
Caution, verbatim from the bottle
Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.
Five instructions in three lines: do not exceed the dose, and four groups who should ask a physician first. The caution paragraph on this bottle is printed cleanly and names the four groups it needs to name: anyone exceeding the dose, pregnancy, nursing, under-18s and anyone with a known medical condition. There is no slip in it to report. The one printed inconsistency worth noticing on this product sits elsewhere: the bottle prints the name as “Sciatica PRO +” and the supplied pack prints it as “Sciatica Pro”, with and without the plus. That is a cosmetic difference rather than a safety one, and it is worth knowing about for one practical reason: if you are searching for the bottle in your hand, you may be searching for the wrong string.
Everything else on this page comes from somewhere else, and the distinction matters. No side effect is published for this product, because no safety study of this formula exists in the supplied material. That is not a safety record. It is an absence of one. What this page can do instead is take the four rows that have a federal consumer page, quote the limits on them, set the printed amount beside each limit, and then say plainly which questions nobody has answered.
9 symptoms that mean contact a provider
A cautions page is where a reader goes when something feels wrong. Some of what can feel wrong is not about a capsule at all.
The red flags, in MedlinePlus’s own wording
Some back and leg pain is not a shopping question. MedlinePlus Medical Encyclopedia, on sciatica, under When to Contact a Medical Professional, prints the instruction as “Contact your provider right away if you have:” and then lists nine symptoms. All nine are below, in MedlinePlus’s own words and in the order it prints them. If any of them describes you, stop reading this site and make the call. Nothing on this page is more important than that, and no supplement is.
Those nine are the ones MedlinePlus puts under “Contact your provider right away if you have:” — they are printed here complete and unedited, because a shortened safety list is a worse thing than no safety list. The same page prints a second and slower list under “Also contact your provider if:”: you have been losing weight unintentionally; you use steroids or inject illicit drugs; you have had back pain before, but this episode is different and feels worse; and this episode of back pain has lasted longer than 4 weeks. Those four are reasons to be seen rather than reasons to go now, and the distinction between the two lists is MedlinePlus’s own rather than this desk’s.
This matters more on a site about this product than it would on almost any other. A capsule bought online is a thing you can start taking tonight without telling anybody, and the one cost of that is the weeks it can absorb while a symptom that needed a clinician goes unreported. If you have any of the symptoms above, the correct next step is a provider, today, not a purchase.
1.7 mg against a 100 mg federal limit
The federal sentence names severe nerve damage. This label prints the Daily Value and not a milligram more.
Now the four vitamin rows, in the order of how much they matter on a nerve product. First, and this is the most important paragraph on the page: vitamin B6 is the one ingredient here where too much causes the very kind of symptom the product is bought because of.
Vitamin B6 is printed at 1.7 mg, which is 100% of the Daily Value and not a milligram more, and on a product sold for nerve symptoms that restraint is the most important decision on the panel. NIH’s Office of Dietary Supplements puts the reason in one sentence: “taking high amounts of vitamin B6 from supplements for a year or longer can cause severe nerve damage”. B6 is the one ingredient here where too much causes the very kind of symptom the product is bought because of. The federal upper limit is 100 mg a day; ODS also notes that EFSA “set an upper limit for vitamin B6 of 12 mg per day for all adults”. The RDA is 1.3 mg for adults 19 to 50, 1.7 mg for men 51 and over and 1.5 mg for women 51 and over — so 1.7 mg is the top of the RDA range and a fraction of either limit. Give the formulator credit for it.
The arithmetic is worth doing out loud, because the restraint is the finding. 1.7 mg against the European figure of 12 mg is about a seventh of it. Against the federal upper limit of 100 mg it is under two per cent. A formulator who wanted the panel to look generous could have printed 50 mg or 100 mg of B6 and still sat under the federal upper intake level while doing it. This one printed the Daily Value and stopped, on a product sold for nerve symptoms, and that decision earns the credit this page pays it.
The one caution that remains is about stacking rather than about this bottle. The ODS sentence is about supplements taken for a year or longer, and the limit is a total from everything you take. If a B-complex, a multivitamin or a second nerve formula is already on the shelf, add the B6 across all of them.
4 of 10 rows with a federal consumer page
Three more rows with published limits, and one masking mechanism worth understanding rather than fearing.
Second, folate — where the real caution is about what a supplement can hide rather than what it can do, and where the order of the two sentences decides whether the point informs a reader or alarms one.
Folate is printed at 383 mcg DFE (230 mcg folic acid) against an RDA for adults of “400 mcg DFE”, which is the 96% on the panel. The upper limit for folate from supplements and fortified foods for adults 19 and over is 1,000 mcg, so this row is at well under half of it — and that has to be said first, or the next point misleads. ODS: “Taking large amounts of folate supplements might hide a vitamin B12 deficiency because these supplements can correct the anemia that the vitamin B12 deficiency causes but not the nerve damage”, and “Large doses of folate supplements might also worsen the symptoms of vitamin B12 deficiency.” 383 mcg DFE is not a large dose. The masking point belongs on this page because the product is taken for nerve symptoms and because the same capsule also carries B12; it does not belong here as an alarm about this amount.
Third and fourth, vitamin B12 and vitamin D3, briefly and in both directions.
The other two vitamins, briefly and in both directions. Vitamin B12 at 2 mcg sits just under the adult RDA of “2.4 mcg”, which is the 83% printed beside it. ODS is direct about why B12 appears on a nerve product at all: “Vitamin B12 deficiency can damage the nervous system even in people who don’t have megaloblastic anemia.” It is equally direct about the limits of supplementing when you are not deficient: on energy, “vitamin B12 doesn’t provide these benefits in people who get enough B12 from their diet.” On safety it is reassuring: “Vitamin B12 has not been shown to cause any harm, even at high doses.” Vitamin D3 at 20 mcg is 100% of the Daily Value, which is the RDA for adults 71 and over (“20 mcg (800 IU)”) and a third more than the RDA for adults 19 to 70 (“15 mcg (600 IU)”). The upper limit is “100 mcg (4,000 IU)”, so this row is at a fifth of it. ODS does not say vitamin D supplements help pain, and on multiple sclerosis — a disease of the nerves — it says “taking vitamin D supplements does not keep symptoms from getting worse or coming back.”
| Row | Printed here | Federal reference | Upper limit | Where this label sits |
|---|---|---|---|---|
| Vitamin D3 | 20 mcg, 100% DV | RDA 15 mcg (600 IU) for 19–70; 20 mcg (800 IU) for 71+ | 100 mcg (4,000 IU) | A fifth of the limit |
| Vitamin B6 | 1.7 mg, 100% DV | RDA 1.3–1.7 mg for adults | 100 mg; EFSA 12 mg a day | Under 2% of the federal limit |
| Folate | 383 mcg DFE (230 mcg folic acid), 96% DV | RDA 400 mcg DFE | 1,000 mcg from supplements and fortified foods | Well under half the limit |
| Vitamin B12 | 2 mcg, 83% DV | RDA 2.4 mcg | None given; ODS says no harm has been shown, even at high doses | Just under the RDA |
All four %DV figures on this panel are arithmetically correct, and the folate row needs a unit conversion first: ODS gives “240 mcg of folic acid and 400 mcg of folate are both equal to 400 mcg DFE” a factor of 1.667, and 230 × 1.667 = 383.3, which the label rounds to 383 mcg DFE.
6 of 10 rows with no federal consumer page
An absence of published side effects is not a safety record. Here is the shape of the absence.
Now the part of a cautions page that usually goes missing, and it is the part a buyer most needs. Here is what is not known about this product, stated as plainly as this desk can put it.
No safety study of these ten ingredients together, at these amounts, in this capsule, exists in the supplied material. Six of the ten rows have no federal consumer page at all — alpha lipoic acid, benfotiamine, acetyl L-carnitine, ashwagandha, broccoli and turmeric — so for those six there is no caution to quote and equally no reassurance to quote. Be precise about what that means, because it is read the wrong way round constantly: no federal page means an absence of published guidance, not the presence of safety.
Nothing supplied to this desk names a drug interaction for any ingredient on this panel. The label’s instruction stands in its place, and it is the right one: anyone with a known medical condition should consult a physician before using this or any dietary supplement. Hand over the bottle with the panel legible rather than a figure off a website.
The label prints a short no-added line — “EGGS, DAIRY, WHEAT, PRESERVATIVES.” — which is a statement about what was not added to the formula. It is not a contains allergen declaration and it says nothing about the facility the capsules were filled in. The other-ingredients line is complete and legible: “Hypromellose (vegetable capsule), Brown Rice Flour, Magnesium Stearate.”
And then the two amounts on this panel that are not trivial, said without softening. Alpha lipoic acid at 400 mg and benfotiamine at 150 mg are real amounts of real compounds. Together they are 550 mg of the roughly 677 mg declared in a serving, which makes them the substance of this formula rather than a garnish. Both were studied at larger doses, in diabetic neuropathy, which tells you the amounts here are not reckless — and neither trial tells you anything about taking them daily for six months alongside eight other things, because neither trial did that. The gap is not between this label and a safety warning. The gap is that nobody published the study.
Three further rows are printed at 25 mg each — ashwagandha, broccoli and turmeric powders. Three rows are printed at 25 mg each: ashwagandha powder (root), broccoli powder, turmeric powder (root). No federal consumer page gives an amount for any of the three for nerve pain, so there is no figure to set 25 mg against and this site assigns them no effect. What can be said is what the panel says: they are present, they are printed, and 25 mg is a small amount of a dried powder — about a fortieth of a gram. All three are listed as powder rather than as standardised extract, and no ratio is printed, so 25 mg is 25 mg.
3 instructions in the storage line
Two pieces of printed text that are instructions rather than claims.
Two more pieces of printed label text belong on a cautions page, because both are instructions rather than claims and both are easy to miss.
Storage and safety seal, verbatim from the bottle
KEEP OUT OF THE REACH OF CHILDREN. DO NOT USE IF SAFETY SEAL IS DAMAGED OR MISSING. STORE IN A COOL, DRY PLACE.
The FDA disclaimer, verbatim from the bottle
THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD & DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.
Read the storage line as three instructions, because it is three: away from children, do not use it if the safety seal is damaged or missing, and store it cool and dry. The middle one is the clearest sentence on the bottle and it gives a buyer grounds to refuse a bottle outright. How to check a bottle covers what to do next if that happens.
The disclaimer is printed in its own ruled box, and both front-of-bottle claims carry a dagger that resolves to it. The front of this bottle carries two claims and no more: “Clinically Studied Ingredients†” and “Supports Nerve Health†”. Both are structure/function claims rather than disease claims, both carry the dagger, and the dagger resolves on the back of the bottle to the full disclaimer: “THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD & DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.” That is the careful way to do it and it should be said plainly. The front does not say the product treats sciatica. It does not say it relieves, eases or cures anything. It says it supports nerve health and it marks the sentence so you can find the disclaimer.
01 Two federal addresses, two different jobs
One address for the product, one for the selling, and two phone numbers that belong to two different organisations.
Finally, where a problem goes, because a cautions page that does not tell you how to report something has only done half the job. The actionable part is short and it has two addresses. A problem with the product — a reaction, a bottle that does not match its label, a claim that a supplement treats a disease — goes to FDA, through MedWatch or the consumer complaint system. A problem with the selling — a charge you did not authorise, a subscription you did not agree to, an advertisement that was not true — goes to the Federal Trade Commission at reportfraud.ftc.gov. Both are free, both take a few minutes, and both work better with the order ID and a screenshot in front of you.
This desk did not run a database search on this product and does not publish one. No search, no date and no result was supplied, and a sentence of the form a search of such-and-such a list on such-and-such a date did not return this product is worth nothing unless the search was actually done. So there is no clearance claimed here, and no absence of a clearance implied either. If you want that check, FDA’s own pages are the place to run it and the sources below link them.
That is a product problem and it goes to FDA, through MedWatch or the consumer complaint system. Keep the bottle, the lot code and the packaging; a report with a lot number on it is worth several without one.
That is a selling problem and it goes to the Federal Trade Commission at reportfraud.ftc.gov. Have the order ID and a screenshot of the checkout in front of you.
The number printed on the bottle beside the distributor is (844) 469-3744. It is a different organisation from the order desk, which is a finding of its own on this product.
The order desk is +1 (302) 200-3480 with the order ID. This website cannot see an order at all, and neither can the number on the bottle.
Questions
None are published for this product, because no safety study of this formula exists. What is published belongs to individual ingredients. The one that matters most here is vitamin B6, and this label is restrained about it at 1.7 mg.
No safety testing of this product has been published and FDA does not test supplements before sale. What can be said: all ten amounts are printed, the four vitamin rows sit at or below their Daily Values and well below their upper limits, and the label carries a real caution paragraph. Six of the ten rows have no federal consumer fact sheet at all, which means no published safety information either way.
Yes, and it is the most important safety sentence on this page. ODS: “taking high amounts of vitamin B6 from supplements for a year or longer can cause severe nerve damage”. The federal upper limit is 100 mg a day and ODS notes EFSA “set an upper limit for vitamin B6 of 12 mg per day for all adults”. This label prints 1.7 mg, which is why it gets credit here rather than a warning.
At large amounts, that is the published concern. ODS: large amounts of folate “might hide a vitamin B12 deficiency because these supplements can correct the anemia that the vitamin B12 deficiency causes but not the nerve damage”, and “Large doses of folate supplements might also worsen the symptoms of vitamin B12 deficiency.” 383 mcg DFE is not a large dose — the upper limit is 1,000 mcg — but mention it to a clinician if a B12 deficiency is possible.
No. 20 mcg is 100% of the Daily Value, it is the RDA ODS gives for adults 71 and over (“20 mcg (800 IU)”), and the upper limit is “100 mcg (4,000 IU)”. It is worth adding up across products if you already take a separate vitamin D.
No interaction study of this product exists, and no federal consumer fact sheet was supplied for alpha lipoic acid, benfotiamine, acetyl L-carnitine or the three plant powders, so no federal interaction is published here for six of the ten rows. Hand the panel to a pharmacist, especially if you take anything for blood sugar, blood pressure or blood thinning.
References
Next
The red flags, the four groups the caution names, and the stacking question.
Read itEvery row, the figure beside it, and the federal page behind it where one exists.
Read itEverything the Supplement Facts panel prints, transcribed and checked.
Read it60 capsules a bottle, two capsules a day, thirty days a bottle. Ten ingredients and ten printed amounts, no proprietary blend, and about 677 mg of declared actives a serving. Price and guarantee are printed on the live checkout, so read them there before you pay. Order support +1 (302) 200-3480.
Price and guarantee are read on the checkout page — screenshot it with the date before you pay · ships from inside the US · order support +1 (302) 200-3480
What this page was checked against
Every figure on this page is either printed on the label or derived from what is printed, with the derivation shown beside it. The medical review sits in the block alongside.
Medical review Dr. Julia Buchfuhrer
A slot stays marked until a real person fills it. Nothing on this site is signed by anybody who has not read it. Who reviews these pages?